This paper deals with the humor that began to be produced in mid-March 2020 and evolved around the Covid-19 pandemic in Greece. Specifically, a corpus of political cartoons coming from popular online newspapers such as “Avgi”, “Efimerida ton Syntakton”, “Kathimerini”, “Ta Nea” and “Athens Voice” concerning the period of the first lockdown from March 16th until May 31st, 2020, was collected and examined. The cartoons which are collected and analyzed are considered political cartoons and produce political humor, since they critically comment on the current events and changes the pandemic has brought about on people’s lives, as well as the measures imposed by the government to prevent it. These cartoons highlighted the way in which cartoonists represented the spread of the coronavirus and highlighted aspects of the health crisis. Also the socio-political perceptions transmitted through the cartoons to produce the humor were examined. Moreover, the way in which cartoonists choose to convey the humorous message through image (visual) and/or language was explored. The analysis of the data was carried out in the framework of Attardo’s “General Theory of Verbal Humor” (GTVH) (1994 ̇ 2001). The findings of the study show that cartoonists targeted prominent figures (politicians, police officers, priests), criticized the measures to combat the virus and highlighted the impact of the coronavirus. Finally, it was shown that the verbal code and the synergy/ collaboration of visual and verbal code are the most frequent ways that cartoonists choose to report/ convey the humorous message to readers.